Hope you all had a great weekend!

Last week, I finally had the chance to dive deep into the insights from the Longevity Med Summit in Lisbon.

Instead of a traditional recap, I synthesized the insights, connecting expert perspectives, mapping key topics, and spotting patterns, to better understand where the field stands today, and where it’s headed next.

There’s often so much noise, we sometimes forget how much real progress is actually being made. But when we zoom out, the signals become clear.

Here are a few takeaways that stood out:

→ Longevity starts before conception.
→ Women’s health is finally being recognized as foundational, not secondary.
→ Oral inflammation is a silent driver of aging.
→ Fasting isn’t just a trend, it’s one of the few interventions proven to support regeneration.
→ Architecture is starting to sync with our biology with buildings designed to align with our circadian rhythms, air quality needs, and emotional states.

The report includes insights from experts like Dr. Miguel Stanley (White Clinic), Dr. Felice Gersh, Chris Moore (Nordic Labs), Anna Bjurstam (Six Senses), Simone Gibertoni (Clinique La Prairie), and many others, pointing toward a future of care that is more measurable, personalized, and deeply human.

If you landed here thanks to the report, welcome, and thank you.

And if you haven’t had chance to read it yet, I hope it offers something useful.

🔗🎧 Read the full report or listen to the podcast summary

This week, we’re exploring:

Latest Drops

Products:
→ AI diagnostics (OpenAI HealthBench) · Sleep tech (Pod 5) · Sound therapy (Apple) · Travel nutrition (Flykitt) · Recovery supplements (AG1)

Spaces:
→ Luxury retreats (Scorpios x Remedy) · New clinics (Biograph) · Longevity hubs (Seveno) · Mindfulness spas (Rituals)

Partnerships:
→ Stride x UNITY · Tally x Cenegenics · ŌURA x CorePower · ŌURA x Open · ŌURA x Luminary

Rundown

→ Enhanced Games · Alzheimer’s blood test

Investor’s Edge

→ AI toilets (Throne) · Bio-acquisitions (23andMe) · Cancer breath tests (SpotitEarly) · Digital health platforms (Strava, Hims & Hers)

⚡ Latest Drops

Products

• OpenAI's HealthBench: OpenAI announced HealthBench, a new tool that puts AI through real medical scenarios to see how well it thinks like a doctor. It’s built to test whether AI can truly help make life-saving decisions.

• Eight Sleep’s Pod 5: Eight Sleep’s latest Pod now includes respiratory tracking and even smarter cooling. It’s like having a sleep coach in your bed, making adjustments while you rest.

• Flykitt's AI Nutrition App: A travel-friendly nutrition app that personalizes hydration and meals based on your location, timezone, and schedule.

• Apple Music's Sound Therapy: Their playlists are tuned with sound healing frequencies to boost focus, calm the mind, and improve sleep, built into your daily rhythm.

• AG1's AGZ Supplement: AG1 introduces AGZ. A clean, science-backed nighttime blend of magnesium, GABA, and adaptogens to help you wind down and recover while you sleep.

Spaces

• Scorpios & Remedy Place Retreat: Remedy Place is teaming up with Scorpios to host an immersive retreat in the Aegean. Think IV drips, breathwork, and ancient wellness rituals by the sea, designed to reset body and mind.

• Biograph's NYC Clinic: Biograph just opened its doors in New York. With advanced diagnostics and spa-like design, it’s raising the bar for what personalized, preventive healthcare should feel like.

• Seveno Capital's Singapore Hub: Seveno is launching a flagship wellness hub in Singapore, combining longevity science with luxury recovery experiences. It’s Asia’s latest leap into the future of proactive health.

• Rituals' Mind Oasis (UK): Rituals is bringing its spa-meets-mindfulness experience to the UK, designed for deep relaxation.

Partnerships

• Stride x UNITY Fitness: Partner to bring real-time biometrics into group fitness, blending personal health insights with collective training environments.

• Tally Health x Cenegenics: Epigenetic data meets physician-led aging programs.

• ŌURA x CorePower Yoga: Yoga meets recovery tech. CorePower instructors now use Ōura data to tailor sessions based on how your body’s actually feeling.

• ŌURA x Open: Breathwork goes biometric. This pairing lets you use real-time recovery data to guide how (and when) you breathe.

• ŌURA x Luminary: A holistic fertility bundle: precision supplements, wearable tracking, and expert guidance.

ŌURA is having a moment. With three major partnerships in a week, they’re building a clear roadmap: become the feedback layer for personal health. From recovery to mindfulness to fertility, ŌURA is positioning itself as the biometric interface between lifestyle and health intelligence.

Expect more brands to build health ecosystems, not just products.

🏃🏽‍♀️ Rundown

Superhuman Sports: The First Enhanced Games Land in Las Vegas

Picture this: athletes who use science to push the limits of the human body. That’s the Enhanced Games, a radical new sporting event where performance enhancement isn’t punished, it’s required.

We’ve all heard of athletes being banned for doping. What if instead of being disqualified, enhancement was the ticket in?

I listened to the Mr. RAD Podcast episode with Aron D’Souza, the founder of Enhanced Games. This isn’t just a sporting event, it’s an experiment turned real. Aron isn’t aiming to replace the Olympics. He’s building a parallel arena that dares to push the human limits, redefining taboos, and testing how far we're willing to go when the rules are rewritten.

Why it’s so provocative:

• It flips the anti-doping narrative, and challenges what we believe is "natural" performance.

• It opens up questions that hit deeper than sport: What does it mean to be human when biology becomes modifiable?

Every athlete must be guided by doctors and health experts. The aim isn’t chaos, it’s exploration. Legal and ethical lines still exist. No cyborg limbs, not shortcuts, just humans at the edge of what’s biologically and technologically possible.

How far is too far when optimizing the human body? The drive to enhance, to overcome our limits, is nothing new. What’s new is the speed, the precision, and the scale.

Fifty years from now, what we call “human” may look very different. And that evolution is already underway…

Trends to Watch:

• Bio-optimization in athletics

• Radical transparency in sport

• Enhanced performance

Alzheimer's Blood Test Gets FDA Approval

Lumipulse is the first FDA-approved blood test for Alzheimer’s diagnosis.

This simple blood test can spot key proteins (p-Tau and Aβ42) associated with Alzheimer’s, making diagnosis less invasive and more accessible than ever. That means earlier intervention, fewer misdiagnoses, and a chance to slow progression.

As blood-based diagnostics replace spinal taps and scans, we may soon catch Alzheimer’s in routine checkups.

Trends to Watch:

• Neurodiagnostic startups

• At-home screening tools

• Preventive neurocare

💳 Investor's Edge

• Throne Raised $4M to analyze gut health via AI-powered toilet add-on.

• WellTheory raised $5M for AI-based autoimmune care platform.

• Strava acquires The Breakaway; valuation hits $2.2B.

• Geviti longevity startup raises $8.5M in Seed Round

• Hims & Hers adds $1B in convertible notes from Morgan Stanley & JP Morgan.

• Sprinter Health raises $55M to expand its at-home healthcare service

• Valerie raises £514K for perimenopause support platform.

• SpotitEarly enters U.S. market with $20M+ with at-home breath test for early cancer detection

• Regeneron to Buy 23andMe out of bankruptcy for $256M

• L’Oréal participated in the $13.8M investment round in the biotech startup Veminsyn.

The integration of diagnostics, at-home testing, and longevity is forming a new strategic category: biological data infrastructure. Startups are turning everyday outputs (breath, stool, urine, saliva, epigenetic markers) into structured, monetizable solutions. The momentum is in real-time, passive systems that unlock scale and engagement.

This signals a shift toward platforms that lower the cost of early detection, scale personalized care, and generate continuous datasets.

But the opportunity also brings challenges, like turning fragmented data into reliable, privacy-first, and truly personalized health intelligence that both consumers and clinicians can actually trust and use.

🔎 Connecting the Dots

Personally, I think we’re on the edge of a much-needed reset. We've spent years collecting health data without really knowing what to do with it. But now, tools are finally catching up and turning that noise into actionable insights.

The possibility of being more in sync with our own biology is truly exciting. Less guessing. More knowing. And maybe, finally, a healthcare system that’s built around people.

Athletes were the first to optimize performance. Now they’re turning it into billion-dollar brands, and shaping the $4.5T wellness market.

They have always been the early adopters.

For decades, they’ve trained with full-stack health teams:

🔬 Precision diagnostics

🧬 Real-time biometrics

🥗 Personalized nutrition

🧠 Neurofeedback and recovery protocols

What’s now trending was standard protocol for them a decade ago.

But here’s what’s changed:

They’re no longer just users.

They’re founders, investors, and early-stage market makers backing the next generation of consumer health and performance brands.

Athletes are the new R&D labs.
Testing what works before the market catches on.

What do athletes know, and why are they backing these brands?

Cristiano Ronaldo → WHOOP & Bioniq

He’s betting on real-time data as the new layer of health intelligence

WHOOP delivers HRV-based recovery insights that guide daily performance. Bioniq’s biomarker-driven supplements close the loop between diagnostics and intervention.

Signal: Continuous health inputs will replace static checkups. Wellness becomes dynamic

Taylor Fritz → Eight Sleep

He sees sleep as the ultimate performance unlock.

Eight Sleep optimizes deep sleep and HRV using real-time biometric feedback and temperature control, critical for recovery and mental clarity.

Signal: Sleep tech will become the anchor of every health stack.

LeBron James → Hyperice & Tonal

He’s betting on recovery and strength as lifelong health strategies.

Hyperice supports injury prevention and muscle longevity through percussive and cryotherapy tools. Tonal delivers AI-guided resistance training for sustainable strength.

Signal: Longevity will be built through mobility and muscular resilience.

David Beckham → IM8Health

He’s co-building consumer longevity from the inside out.

IM8 blends NASA-level R&D with clinical-grade diagnostics to create accessible, precision health products for proactive aging.

Signal: Wellness is becoming more clinical, without feeling clinical.

Maria Sharapova → Aman & Therabody

She’s turning recovery into a ritual, not just a tool.

At Aman retreats and through Therabody tech, she’s championing breathwork, muscle repair, and nervous system resets as daily longevity habits.

Signal: The next wellness stack blends science with sensory experience.

Roger Federer → On Running

He’s designing for movement across a lifetime.

As co-owner, Federer’s guiding On toward footwear that enhances biomechanics, prevents injury, and sustains performance into post-athletic life.

Signal: Performance wear is shifting from speed → durability → longevity.

Serena Williams → Serena Ventures

She’s backing the underfunded future of health: femtech, wellness, and biotech.

Her portfolio reflects a bet on overlooked founders solving critical needs in hormone health, diagnostics, and recovery.

Signal: The wellness boom will be female-led and medically integrated.

Rafael Nadal → Technogym

He’s focused on smart strength for long-term mobility.

Technogym’s intelligent equipment supports rehab, flexibility, and functional power, essential for performance past peak years.

Signal: Rehab and strength training will converge into everyday wellness.

Eliud Kipchoge → Abbott Libre Sense | Lingo

He’s using glucose tracking to fine-tune performance in real time.

By tracking metabolic response mid-race, Kipchoge shows how real-time fuel monitoring drives precision endurance.

Signal: Metabolic optimization will become mainstream for all high-performers.

Diogo Dalot → Bioniq

He’s making a high-conviction bet on personalized performance nutrition.

Dalot sees biomarker-driven supplementation as foundational to recovery and injury prevention.

Signal: Personalized protocols will replace one-size-fits-all vitamins.

Austin Krajicek → Alphabeats

He’s treating cognitive recovery like physical training.

Alphabeats uses EEG neurofeedback to sharpen focus, enhance recovery, and improve stress resilience.

Signal: Brain performance will become a daily training category, just like physical strength.

💡 The Pattern

Athletes aren't backing trends.

They’re betting on what they already know works, and what the broader wellness market hasn't fully caught up to yet.

They see the gap between traditional health and actual performance.
And they’re building the bridge.

They bring what the wellness industry needs most: credibility, visibility, and urgency.

They were the first to need this tech, and now they’re turning sports science into everyday tools for recovery, longevity, and performance.

So why do we trust athletes more than doctors?

Because they have what the system doesn’t:

Skin in the game. Real-time data. And results we can see.

We’re not following them for expertise.

We’re following them because they live what they preach….and it works.

What does that say about where wellness is headed?

Yesterday’s blackout forced an unexpected reset.

No electricity, no internet, just silence, slowness, and a rare chance to step back from the usual flood of information. I spent the day outside, writing and reading, a kind of disconnection that, ironically, made me feel more connected.

Losing power yesterday reminded me of how much we rely on things we barely notice until they’re gone. When everything’s working, we don’t think about it. It's only when the lights go out that we realize how dependent we really are.

Health is the same.

We go through life assuming it’s there, quietly keeping us going. But when something goes wrong, everything else stops. And unlike a blackout, sometimes there’s no easy way to turn it back on. The damage is invisible until it’s too late.

That’s why I’m so excited about the big shift happening in health right now!

We’re moving from a reactive system to a proactive one. From waiting for problems to show up, to designing environments and tools that help us stay ahead. Prevention, brain health programs, AI diagnostics, high-tech wellness spaces, they’re no longer abstract ideas. They’re becoming part of our everyday lives.

And this shift isn’t just personal. It’s collective.

That’s what I see reflected in this year’s Netherlands Pavilion for Expo 2025 by RAU architects in Osaka.

A light sphere that reflects a deeper message:

‘Common Ground’ extends this ethos to a global scale, emphasizing collective responsibility in addressing finite resources and planetary boundaries.

We need this kind of vision.

Not just in architecture, but in how we approach health, energy, and life itself.

This week, we’re exploring:

Drops:

• Bioniq enters Remedy Place with personalized supplements.

• Lifeforce launches a Brain Protection Program.

• Viome releases an AI-Powered Full Body Intelligence™ Test.

• Neko Health opens its largest center yet in London.

• Fountain Life, Humanaut Health, and Clinique La Prairie expand longevity spaces.

Rundown:

• A humanoid robot wins a half-marathon.

• Patients in VR during surgery need less anesthetic

Investor's Edge:

• Major rounds: Superpower ($30M), Biolinq ($100M), Ovo Labs (£4M), Skin Analytics (£15M), and a new $70M longevity fund.

⚡ Latest Drops

Products

Bioniq Expands Into Remedy Place's Wellness Clubs

Precision health meets social wellness clubs.

Bioniq, hyper-personalized supplements, now brings its blood-based health solutions to Remedy Place's wellness clubs, creating a new integrated health experience. Their Meridian platform tracks your blood biomarkers and adjusts your supplement plan quarterly.

Your supplements could actually reflect what your body needs today, not what worked for you a year ago.

This is a step toward hyper-personalization. Easy access to real-time biomarker tracking = smarter, more customized wellness journeys.

Key Trends to Watch:

• Real-time, adaptive supplementation

• Wellness spaces integrating diagnostics

Read More →

Viome Unveils AI-Powered Full Body Intelligence™ Test

Viome dropped its biggest play yet: combining microbiome, mitochondrial, and oral health data into one predictive test, powered by AI.

Biological aging is now measurable, and modifiable, think of it as a "health GPS" steering you away from future health issues before they even appear.

Key Trends to Watch:

• AI-guided preventive diagnostics

• Consumer control over biological age and health span

Read More →

Lifeforce Launches Brain Protection Program

Cognitive longevity is the next frontier. Lifeforce’s program uses lab testing, clinician consultations, and nootropics to optimize brain health and reduce dementia risks.

Early intervention could be the biggest weapon against cognitive decline.

Key Trends to Watch:

• Cognitive optimization becomes mainstream

• Longevity clinics diversify services

Read More →

Spaces

Neko Health Opens Largest Center in London

Neko Health just launched their biggest health center in Spitalfields, London. Offering AI-driven full-body scans in 10 minutes (with zero radiation) Neko is making preventive health sexy, fast, and consumer-first.

Get Early Access by Signing Up with This Link →

Read More →

Fountain Life Expands to One Thousand Museum in Miami

Combining early diagnostics, performance optimization, and concierge medicine, Fountain Life is bringing a luxury wellness space together under one iconic roof. Inside the futuristic One Thousand Museum tower, a masterpiece designed by Zaha Hadid Architects.

Read More →

One&Only Resort + Clinique La Prairie: Hudson Valley Ultra-Luxury Wellness

One&Only Resorts is partnering with Clinique La Prairie to launch a new ultraluxury resort and Longevity Hub in Hudson Valley.

Travel meets health optimization, bringing premium preventive health and rejuvenation experiences to luxury destinations.

Read More →

Humanaut Health Expands to Florida

Humanaut Health, known for its data-driven longevity protocols, is expanding into Florida, offering advanced diagnostics, personalized care, and wellness optimization programs.

Read More →

🏃🏽‍♀️ Rundown

Humanoid Robots Are Entering the Health Race

Tien Kung Ultra just won the world's first humanoid robot half-marathon in Beijing. A 21 km robot endurance milestone.

Meanwhile, at labs like Insilico Medicine, robots are already learning how to design new AI-generated drugs.

Robotic companions, AI-designed therapies, and smart diagnostics are redefining how health innovations are created and delivered. The future of healthcare is being shaped by machines that can think, move, and heal alongside us.

Key Trends to Watch:

• Robotics in health diagnostics, elder care, and mobility aids

• AI-driven healthcare innovation pipelines

Read More →

Patients in Virtual Reality During Surgery Need Less Anesthetic

MIT Tech Review reported that patients immersed in calming VR scenes during surgery needed significantly lower anesthesia doses, showing the powerful mind-body connection.

VR isn’t just for gaming. It could transform surgical safety, recovery time, and patient experience.

Key Trends to Watch:

• VR pain management

• Non-pharmaceutical interventions rising

Read More →

💳 Investor's Edge

• Biolinq Raises $100M for Wearable Metabolic Biosensor Development.

• Superpower Raises $30M for World's First Health Super-App.

• Ovo Labs Secures £4M to Expand Fertility Solutions.

• Skin Analytics Lands £15M for Autonomous Skin Cancer Diagnosis.

• PhotoPharmics closes $6M to advance Parkinson’s device.

Investment is surging toward platforms that blend diagnostics, digital health, AI, and preventive therapies. A strong signal that the future of health is deeply personalized and tech-powered.

📈 Market Perspective

• Preventive health is no longer a niche. It’s becoming the foundation of modern wellness, driving demand for full-body diagnostics and precision interventions.

• AI and robotics are reshaping healthcare from the inside out, accelerating drug discovery, improving diagnostics, and enhancing patient care.

• The future of health is hyper-personalized, data-driven, and tech-augmented, as consumers seek earlier insights, smarter interventions, and longevity-focused lifestyles.

🔎 Connecting the Dots

The boundaries between tech, longevity, and wellness are disappearing fast.

From wellness hubs opening luxury residences to AI designing next-gen therapies, the convergence of health-tech, AI, and consumer empowerment is creating a new standard for living better, longer.

What’s your take?

Between resurrected wolves and mood-sensing AI, the lines between biology, tech, and everyday wellness are dissolving.

• What used to feel experimental is now being productized.

• What used to be elite is starting to scale.

• What was reactive is becoming precision-based and preventive.

Here are some of the most interesting signals shaping the future of longevity, healthspan, and performance this week:

• Latest Launches

  • Timeline Dropped an Eye Cream Product

  • OneSkin Expanded Into Scalp Health

  • ElevenLabs’ Conversational AI is now HIPAA-Compliant

• This Week’s Rundown

  • From Reactive To Intuitive AI — Anastasia Georgievskaya

  • Longevity Is A Full-Scale Economic Shift — Dr. Marta Ra

  • Longevity Clinics Are Scaling, But Missing the Foundation — Gari Zmudze

  • Gyms Are Quietly Becoming Longevity Clinics — Delphine Le Grand

  • The Dire Wolf Is Back: What De-Extinction Means for Human Longevity

• Must Reads + Listens

  • Optimizing Human Health — Dr. Fady Hannah-Shmouni

  • Want to stay young? Survive the next 10 years — Peter Diamandis

Latest Launches: New Tools for the Long Game

Timeline’s Eye Cream

Timeline dropped a new product:

→ Eye Cream with Urolithin A to target cellular aging around the eyes at the mitochondrial level.

💡 Why it matters: Mitochondrial health is quietly becoming the front line of anti-aging. This is biotech wrapped in skincare.

👀Just a heads-up: Timeline has another first-of-its-kind product dropping on April 14 — Stay tuned.

View New Product →
Use code: BIOCOMPASS for 10% off!

**UPDATE

Timeline’s Mitopure Gummies Have Arrived!

→ A new way to slow muscle loss with age. Urolithin A gummies work at the cellular level.

💡 Why it matters: We lose up to 8% of muscle per decade after 30. Timeline’s tackling it from the mitochondria up.

Try the new Mitopure Gummies for FREE. While supplies last! →

OneSkin’s OS-01 HAIR Serum

OneSkin expanded into scalp health with a peptide serum that targets cellular senescence at the follicle level.

📈 76% saw new hair growth in 3 months.

💡 Skin and hair aren’t cosmetic anymore, they’re therapeutic surfaces.

Aging isn’t just about skin, your scalp ages too. And OneSkin is treating it like a living organ.

Explore Product →

ElevenLabs’ HIPAA-Compliant Conversational AI

Eleven Labs just announced their conversational AI is now safe for healthcare use, meaning it can securely handle reminders, notes, coaching, documentation, and patient interaction.

💡This is huge. If AI is going to scale in healthcare, it needs trust and privacy baked in, and ElevenLabs just took a big step in that direction.

Read More →

This Week’s Rundown:

🧠 From Reactive to Intuitive AI

Anastasia Georgievskaya — Haut.AI

In her recent Forbes feature, Anastasia explores the rise of intuitive AI as a technology that can interpret micro-expressions, tone of voice, and emotional states in real time.

It’s already being used in skin diagnostics.

But the implications go far beyond skincare, into mental health, wellness, and how we interact with healthcare itself.

💡 Why it matters:

• We’re moving from prompt-based tools to systems that sense us.

• Skin, tone of voice, and emotional patterns are becoming real-time inputs for personalized care.

As AI becomes more human, it won’t just respond.

It will anticipate, and quietly reshape how we experience health support.

Read Article →

💳 Longevity is one of the most consequential economic and societal transformations of our time

Dr. Marta Ra, in conversation with Julius Baer, reframes longevity as a societal redesign, not a wellness trend.

Just like climate or AI, longevity is a macroeconomic force. This isn’t just about living longer. It’s a full-scale economic shift, a redesign of how we live, work, invest, insure and age.

• Healthspan > Lifespan

• Aging = Economic Pressure + Opportunity

• Women = Driving Health + Wealth Decisions

• Access = The Great Divider (or Multiplier)

💡Why it matters:

→ This is about systemic redesign, not just supplements.

→ The 100-year life needs a new operating system.

Must Read →

🔬 Longevity Clinics Are Scaling — But Missing the Foundation

via Gari Zmudze | Longevity Clinics Survey 2025

There’s momentum in the clinic space, but cracks are showing.

According to the Longevity Clinics Survey 2025:

The good news:

• Clinics are adopting advanced diagnostics

• Wearables and biological age testing are becoming standard

• Demand is rising fast, specially from Gen X

The gaps:

• 77% plan to expand, but only 39% are profitable

• There’s no standardized training for longevity doctors

• Many skip core diagnostics like cognition, hearing, and oral health

💡 Gari Zmudze’s take:

The future isn’t more clinics. It’s smarter infrastructure:

→ Centralized expertise + distributed, at-home diagnostics

→ Monthly biomarker tracking

→ Seamless digital coordination

This is concierge care, but built to scale, not just for the elite.

Because longevity’s real challenge isn’t science.

It’s systems.

Read Post →

Read Full Report →

🏃🏽‍♀️ Gyms Are Quietly Becoming Longevity Clinics

via Delphine Le Grand

Equinox, Life Time, Love.Life, Remedy Place, and THE WELL, are blurring the line between fitness and medicine, offering diagnostics, recovery, coaching, even IV therapy.

Why it matters:

• Gyms have what clinics lack: habit, frequency, motivation.

• They’re fast, consumer-first, and designed to scale.

💡 Connecting The Dots

As longevity medicine struggles to find a profitable, scalable delivery model...gyms may quietly be solving it.

They’re not just spaces to train, they’re evolving into everyday infrastructure for prevention, recovery, and biological optimization.

The future of care may not come from inside the clinic.

It might come from where we already show up.

Read Full Post →

🐺The Dire Wolf Is Back: What De-Extinction Means for Human Longevity

I had to read it twice.

Colossal Biosciences brought back two Dire Wolves.

Extinct for 10,000 years. Alive again through synthetic biology.

At first glance, it sounds like science fiction. But if we zoom in, there’s something bigger:

🧬 The same biotech tools used to resurrect extinct species are reshaping the future of human health:

• Reprogramming aging cells

• Regenerating damaged tissue

• Extending cellular function and resilience

So, what does this have to do with your future lifespan?

Everything.

While bringing back extinct species and extending human life seem like different goals (reviving species versus extending human healthspan), they rely on the same core technologies: gene editing, cell reprogramming, and genetic engineering.

🔍 De-extinction shows we can take DNA and rebuild life from it.

Now imagine using that same power to reverse aging.

If we can rebuild life from the past, can we rebuild time within the body?

Of course, longevity is tricky.

And yes, it raises big questions:

If we can rebuild life... what risks do we unleash?

But also:

If we get it right, we’re not just adding years.
We’re rewriting what life can be.💭 ✨

Read Full Story →

Must Reads + Listens

🎙️ Podcast: Optimizing Human Health

Dr. Fady Hannah-Shmouni on Personalized Medicine and Longevity

In this deep conversation at the Mizter Rad Show, Fady shares why the future of healthcare is proactive, personalized, and predictive. This model aims to prevent disease altogether and optimize you before problems emerge.

“We can decelerate aging. We can create healthy, optimized humans.”

→ Your biology will become a digital twin, constantly monitored and optimized

→ Quantum medicine, multi-omics, organoids, stem cells. All of it is real, now

→ Hormonal aging could soon be reversible

🎧 Listen Here →

🧠 Article: Want to stay young? Peter Diamandis says survive the next 10 years

Peter explains how longevity tech is accelerating, and that the key is just staying healthy long enough to benefit.

“There will be a point where, for every year you’re alive, science adds more than a year to your life.”

→ We may be hitting "longevity escape velocity"

→ Most powerful (and free) intervention? Mindset.

→ Epigenetic reprogramming and cellular repair—is coming fast.

→ $157M XPRIZE is now underway to reverse aging by 2030

📖 Read on TechCrunch →

💡 Apply to the XPRIZE Longevity Investor Summit →

If you made it this far, that says a lot. You’re probably one of the people building, investing, or thinking ahead, and that’s who this is for.

Thanks for following along.

See you in the next one.

Aging isn’t what it used to be. It’s no longer just about adding years to life but ensuring those years are vibrant, and energetic. At the forefront of this transformation are remarkable women whose latest ventures and achievements are pushing the boundaries of what’s possible in longevity science.

From AI-powered diagnostics to gene therapy breakthroughs, these women are proving that the future of aging is not just about science, it’s about redefining what it means to thrive at every stage of life.

Meet the Women Shaping the Future of Longevity

Joanna Bensz

CEO, Longevity Center

Joanna Bensz is redefining healthcare by integrating advanced diagnostics and epigenetics into Longevity Centers across Europe, showcasing how precise healthcare can enhance both lifespan and healthspan.

Joanna's vision combines advanced diagnostics with holistic health strategies, empowering people to take charge of their health, detect issues early, and optimize their well-being for the long run. Her commitment to international collaboration is driving global progress in aging research, shaping the future of longevity.

Latest News & Milestones:

• The Longevity Center, expanded to Zurich, opening a state-of-the-art center with continuous biomarker monitoring, diagnostics, and personalized health programs.

• Launched the Brain & Memory Lab in collaboration with neurologist Dr. Stanisław Szlufik, pioneering cognitive-function optimization protocols for prevention and neurodegenerative conditions management

• Hosted the Buck Institute Clinics Roundtable, setting global standards in longevity for longevity clinics.

Celine Halioua

Founder & CEO, Loyal

Celine is pioneering longevity drugs for dogs! Through Loyal, she’s developing FDA-approved longevity drugs for dogs, that could eventually translate to humans.

By extending healthy lifespan in dogs, Celine’s work helps fast-track discoveries that could one day slow aging in humans! Her research isn’t just about dogs; it’s paving the way for science-backed longevity solutions that could directly impact our own well-being.

Latest News & Milestones:

• Loyal’s drug candidate LOY-002 cleared a major FDA milestone, becoming the second approved longevity therapy for dogs!, bringing canine longevity closer to market.

• Loyal raised $22million in new funding.

• Loyal Launched STAY study, enrolling 1,000 senior dogs to evaluate the impact of LOY-002 on healthy lifespan.

Elizabeth Parrish

CEO, BioViva

Liz isn’t just advocating longevity; she's living proof. As the first person to undergo experimental gene therapy aimed at cellular rejuvenation, she’s testing the limits of regenerative medicine at BioViva.

Her fearless approach to self-experimentation and advocacy for genetic solutions is accelerating breakthroughs that could one day help us stay healthier for longer.

Latest News & Milestones:

• Elizabeth Parrish, CEO of BioViva, will be speaking at the Longevity Summit Dublin 2025

• Early trials of BioViva’s telomerase + Klotho gene therapies showed promising cognitive improvements in dementia patients.

• Their CMV vector increased mouse lifespans by 41.4%, sparking hope for future therapies against Alzheimer’s and muscle loss.

• BioViva successfully raised Series A funding, showing wider acceptance to advance gene-therapy research.

Kayla Barnes

CEO, LYV Wellness & Co-Founder, The Health Optimization Fund

Kayla Barnes is proof that longevity isn’t just a science, it’s a lifestyle. As the owner of LYV Wellness, and a Female Longevity Community, Kayla empowers women, through practical, data-driven longevity programs. She also hosts the Longevity Optimization Podcast, where she shares actionable insights and expert discussions.

Kayla makes longevity accessible and achievable. With a focus on women's health and longevity optimization, she translates complex science into actionable strategies.

Latest News & Milestones:

• LYV Wellness introduced advanced clinical programs, including multi-omics profiling and exosome injections aimed at reducing cellular senescence and optimizing real-time protocols.

• She published a comprehensive female longevity data set and created a Female Longevity Membership, reaching over 300,000 women worldwide.

• Started the Longevity Optimization Podcast, featuring discussions with top experts from around the world.

Dr. Amy B. Killen

Longevity & Regenerative Medicine Physician, Co-founder at Humanaut Health

Amy is revolutionizing regenerative medicine, specializing in longevity-based aesthetics, sexual health, and hormone optimization. She’s known for her work in stem cell therapies and platelet-rich plasma (PRP) treatments.

She bridges the gap between cutting-edge regenerative therapies and everyday well-being, proving that true longevity is about thriving with energy, vitality, and confidence.

Latest News & Milestones:

• Humanaut Health raised $8.7 million in seed funding to expand personalized longevity clinics, making high-end regenerative therapies more accessible.

• Amy launched the Human Optimization Project (HOP) Box, a doctor-formulated supplement kit designed to enhance women’s longevity.

• She is speaking at the Longevity Docs Hormones & Longevity Mastermind event in New York City on March 29th, 2025

Nikolina Lauc

CEO, GlycanAge

Nikolina is at the forefront of glycobiology, pioneering ways to measure biological age through glycan-based biomarkers. Her company, GlycanAge, provides personalized health insights through simple at-home testing.

Nikolina Lauc turns lab research into practical tools, helping you measure and improve your biological age with real data, so you can take control of your health and aging journey.

Latest News & Milestones:

• GlycanAge raised $4.2 million in seed funding, accelerating global expansion of its glycan-based diagnostic platform.

• In 2023, Nikolina, was recognized as the Entrepreneur of the Year in Croatia

Dr. Casey Means

Co-Founder, Levels

Casey is a pioneer in metabolic health and co-founder of Levels, a platform that uses real-time glucose monitoring and AI-driven insights to empower healthier lives.

Dr. Casey helps you understand how stable blood sugar and balanced energy aren’t just health trends, they’re the foundation for a longer, healthier life. Her work shows that optimizing your metabolism can sharpen your mind, boost daily energy, and reduce long-term disease risk.

Latest News & Milestones:

• Levels secured a $10 million Series A, including $3 million in crowdfunding from over 2,000 investors to democratize glucose monitoring.

• Dr. Casey Means co-authored the #1 New York Times bestseller "Good Energy: The Surprising Connection between Metabolism and Limitless Health," which has been on the bestseller list for months

Dr. Andrea Maier

Co-Founder, Chi Longevity & Professor, NUS

Andrea blends research and practice, helping people adopt scientifically proven interventions for healthier aging through her Chi Longevity clinics.

She is a leading force in aging research, making longevity science accessible and cutting through the hype with evidence-based solutions. She champions personalized interventions based on your unique biomarkers, shifting the focus from generic supplements to targeted strategies that truly impact health and longevity.

Latest News & Milestones:

• Chi Longevity opened its second clinic at the Four Seasons Hotel Singapore, expanding its presence in Asia and marking a shift toward luxury, data-driven longevity treatments geared toward individuals seeking precision health solutions.

• She Co-hosted the Founders Longevity Forum addressing APAC’s aging challenges and reinforcing Singapore’s leadership in geroscience.

Dr. Evelyne Bischof

Physician-Scientist, President at Healthy Longevity Medicine Society

Evelyne is championing AI-driven longevity medicine, setting standards for predictive diagnostics and precision longevity therapies worldwide. She also directs the Longevity Department at the renowned Sheba Medical Center in Israel, integrating geroscience into hospital practice.

Her work is unique. It’s not just about one discovery. It’s about building an entire ecosystem: educating doctors, setting clinical guidelines, and ensuring that longevity breakthroughs actually reach patients.

Latest News & Milestones:

• Dr. Evelyne was appointed President of the Healthy Longevity Medicine Society (HLMS), she launched a global initiative to standardize AI-powered biomarkers and clinical protocols for longevity.

• She played a significant role in the 2024 Longevity Investors Conference in Davos, Switzerland, participating in multiple panels on topics such as "Latest Developments in Longevity and AI" and "A Roadmap to Sustainable Health and Better Wellbeing in the Workforce and Society"

• Continues her role as Medical Director of the Sheba Longevity Center at Sheba Medical Center, affiliated with Tel Aviv University, while also serving as a professor at Shanghai University of Medicine and Health Sciences

Nabiha Saklayen

Co-Founder, Cellino

Nabiha Saklayen is using laser-based technology to revolutionize stem cell therapies, making regenerative medicine more precise and scalable.

Her work is paving the way for affordable, accessible regenerative medicine, bringing cutting-edge cell therapies closer to those who need them. This could mean a future where treating chronic diseases is faster, more effective, and within reach for more people.

Latest News & Milestones:

• Cellino just announced a partnership with Matricelf to scale iPSC-based spinal cord injury therapies.

• Cellino launched The Foundry; the first AI-powered hospital-based iPSC manufacturing facility. Advancing their goal of making patient-specific stem cell-derived therapies available for broad patient audiences

• Cellino was awarded $25M in funding from the ARPA-H, to drive the development of their biomanufacturing technology for personalized regenerative medicine.

Anastasia Georgievskaya

CEO, Haut.AI

Anastasia Georgievskaya is transforming skincare with AI-driven solutions that personalize beauty and longevity interventions, making cutting-edge technology accessible.

Her AI-driven approach to skincare helps you understand your skin’s unique needs, using data to predict and prevent aging signs before they appear. By combining science and technology, she’s making smarter skincare choices effortless.

Latest News & Milestones:

• Haut.AI’s commercially launched SkinGPT, generative AI platform that simulates the effects of skincare products and treatments, revolutionizing virtual skincare try-ons for beauty brands.

• They introduced "Generative Skin: Library of Ingredient Effects," an interactive website allowing users to visualize the impact of various skincare ingredients on their skin through AI-generated simulations

• Haut.AI was granted a United States patent for its Skin Atlas system, which provides detailed skin analysis and personalized skincare recommendations while ensuring user privacy through advanced anonymization techniques

Carolina Reis & Alessandra Zonari

Co-Founders, OneSkin

This duo is redefining skincare by targeting the root causes of aging at the cellular level through pioneering longevity-focused topical treatments.

They’re proving that longevity science isn’t just for the future—it’s for your skin today. By using peptide technology to slow cellular aging, they help you maintain healthier, more resilient skin for the long run.

Latest News & Milestones:

• Their patented Peptide OS-01 has been scientifically proven to reverse skin's biological age by preventing the accumulation of senescent cells, positioning OneSkin as a leader in science-led topical skin longevity treatments

• OneSkin secured a $20 million Series A funding round, with Unilever Ventures among its key investors, signaling potential industry collaborations.

• OneSkin was recognized by Fast Company as one of 2024’s Most Innovative Companies, OneSkin is expanding its product line to further integrate molecular-level skin health solutions.

Dr. Elisabeth Roider

Partner & CSO, Maximon

Dr. Elisabeth Roider is a physician-scientist specializing in longevity biotech. She is the Chief Scientific and Medical Officer at Maximon AG, where she helps startups develop innovative solutions for healthy aging. She also works at University Hospital Basel and Harvard Medical School, contributing to advanced research in aging and regenerative medicine.

Her work bridges science and innovation, bringing breakthroughs breakthroughs in longevity into real-world solutions that may slow aging and improve quality of life.

Latest News & Milestones:

• Ayun Longevity Clinic launched in Zürich under Elisabeth’s leadership, offering advanced diagnostics and personalized treatments.

• She oversaw the launch of a CHF 100 million Longevity Co-Investment Fund, supporting startups focused on aging interventions and longevity biotech.

• She joined Maximon's leadership team as Partner and Chief Scientific and Medical Officer in 2022, bringing her expertise as a Harvard- and Swiss-trained physician-scientist to drive innovation in the longevity field

Dr. Alexandra Bause

Co-Founder & Partner, Apollo Health Ventures

Alexandra is shaping the future of longevity biotech as a Co-Founder and Partner at Apollo Health Ventures, a leading venture capital firm funding cutting-edge companies developing therapies to extend human healthspan.

Her vision ensures that longevity research transitions from the lab to transformative therapies. She focuses on high-impact investments and supports biotech startups from early-stage research to commercialization.

Latest News & Milestones:

• Apollo Health Ventures' portfolio company, Auron Therapeutics, Inc., recently received FDA approval for their investigational drug AUTX-703 and raised $27M in Series B funding to initiate Phase 1 trials in hematologic malignancies.

• Refoxy Pharma, successfully raised €9.1M in a seed-extension financing round to accelerate the preclinical development of novel FOXO3 activators targeting idiopathic pulmonary fibrosis

• Apollo-backed Ochre Bio secured a $1 billion deal with Boehringer Ingelheim for AI-driven liver disease therapeutics.

These women are not only shaping the future of longevity, they’re making it personal. Their work is turning aging into an opportunity to thrive.

As we follow their journeys, one thing is clear: the longevity revolution is powered by passion, innovation, and a belief that every stage of life can be lived to its fullest.

We’re also testing a fresh newsletter format to make insights sharper, deeper, and more actionable, let us know your thoughts 💭

This week, we’re exploring:

• Health-Tech Breakthroughs – From body scans to AI-powered innovation.

• AI & Longevity – Can AI help us live longer?

• The City of the Future – How Próspera is rethinking healthcare innovation.

• Market Perspective – Longevity takes center stage

• Actionable Takeaways – Improve your health today.

Let’s dive in!

The Latest in Health-Tech & Longevity

Neko Health Raised $260M to Revolutionize Preventive Care

Co-founded by Spotify’s Daniel Ek, Neko Health is reimagining healthcare with advanced body-scanning technology. Now valued at $1.8B!

Currently available in Stockholm and London, they’re expanding globally, with U.S. expansion in sight.

What sets Neko Health apart—and what many may not fully realize—is that we are a fully integrated tech company. We build our own devices, develop our software, and design our health centers. This approach was intentionally designed by Hjalmar Nilsonne and Daniel Ek from the very beginning, and their strategic decisions are now paying off in remarkable ways. Our ability to iterate quickly and control the entire experience has been pivotal to our success.

What also stands out is our focus on design and user experience. There’s truly nothing else like it.

Kim Fai Kok – Comms & Marketing at Neko Health
Read Full Post

What’s in it for you?

• Most chronic diseases are preventable if detected early. Neko’s, non-invasive full-body scans make it easier to catch risks early, empowering you to take control of your health before problems arise. And the best part? It’s expanding to more locations soon!

Why it matters:

• This is more than a cost-saving shift—it’s a wake-up call for a healthier future. Neko is betting big on prevention and early detection as the future of healthcare.

Read More

Ultrahuman x InsideTracker: Next-Level Heart Health Insights

Ultrahuman, known for its smart ring, and InsideTracker, a pioneer in blood analysis, have joined forces to launch Blood Vision. This platform offers U.S. users advanced, real-time cardiovascular insights powered by biometrics and personalized blood analysis to deliver real-time insights into cardiovascular health.

Why it’s exciting:

• Imagine wearing a device that not only tracks your vitals but integrates your bloodwork to give you actionable, personalized tips. This partnership makes that possible, giving you control over your heart health.

Pro tip:

• This is a glimpse of the future, where wearables aren’t just for fitness, but for truly optimizing your health.

Read More

Will AI be the Catalyst for Human Longevity?

Anthropic CEO Believes AI Could Double Lifespans in 5-10 Years

Speaking at the World Economic Forum in Davos, Dario Amodei, CEO of Anthropic predicted AI could compress a century of biological progress into a decade, possibly doubling human lifespans in 5-10 years.

Why it’s huge:

• AI models are accelerating drug discovery and genetic research, leading to breakthroughs in cellular regeneration and disease prevention. 💡Think faster treatments and therapies designed just for you, powered by AI’s ability to decode biology.

Read More

The OpenAI Model to Extend Life

OpenAI and Retro Biosciences unveiled GPT-4b micro, an AI model that engineers proteins, like Yamanaka Factors, which can reverse cellular aging and repair tissues.

How it could help you:

• Picture a future where damaged cells are repaired, and aging is slowed—potentially giving you more years of vitality.

Why it’s game-changing:

• AI isn’t just predicting diseases; it’s rewriting how we treat and prevent them. Longevity science is on the verge of going mainstream.

Read More

Building the City of The Future

Próspera’s Vision Backed by Coinbase

Próspera, an innovative economic zone in Roatán, Honduras, is gaining momentum with support from Coinbase and other major investors. Its goal? To increase global economic freedom while pioneering groundbreaking solutions in healthcare.

Operating under a unique legal framework called ZEDE, Próspera has autonomy from the Honduran government, allowing it to create a more dynamic, innovation-friendly environment.

Connecting the dots:

• Economic freedom and healthcare are deeply intertwined. By creating environments where regulatory hurdles are minimized

What it means for you:

• Innovations born here could make advanced treatments more accessible, faster, and more affordable.

Read More

📈 Market Perspective: Longevity Takes Center Stage

These developments reflect a massive market appetite for longevity solutions:

• Prevention-first solutions like body scans and wearables are getting major investment.

• Consumers want integrated, personalized, data-driven health options.

• AI is driving innovation, accelerating funding and commercialization in longevity science.

• Environments like Próspera highlight the need to reduce regulatory hurdles to scale health-tech globally.

🏃🏽‍♀️ Actionable Takeaways

Think Preventive:

Start prioritizing early detection. Regular scans and blood tests can reveal risks before they become problems.

Stay AI-Savvy:

Follow advancements in AI-driven health innovations, from regenerative medicine to personalized therapies.

Own Your Health:

Use wearables and diagnostic tools to track your metrics and craft tailored wellness strategies for peak performance.

💡 Closing Thought

The fusion of AI, economic innovation, and health-tech is creating a once-in-a-lifetime opportunity to not only live longer but live better.

Whether it’s cutting-edge diagnostics or rethinking healthcare systems altogether, the future is happening now!

What’s your take? Share your feedback on this new format or the topics covered, we’d love to hear from you!

Imagine starting your day by looking into a mirror that not only shows your reflection but also provides a complete health assessment. Withings, a leader in connected health devices, is bringing this idea closer to reality with their latest concept unveiled at the CES 2025: the OMNIA AI-powered smart mirror for at-home health assessments.

A New Era of Health Tracking

OMNIA transforms an everyday morning routine into an intelligent health hub that seamlessly integrates with the Withings ecosystem, from smart scales, blood pressure monitors, and sleep analyzers, providing a daily view of your health.

What Makes OMNIA a Game-Changer?

• Health Metrics made Personal

OMNIA tracks over 60 health indicators, including heart health, body composition, sleep quality, skin hydration, and activity levels.

• AI That Speaks Your Language

A built-in AI assistant analyzes your data and gives you meaningful advice. It might suggest a high-protein breakfast after a poor night’s sleep or recommend stretching to ease tension. It’s practical, actionable, and tailored to your life.

• At-Home Doctor’s Office

The concept envisions seamless connectivity with healthcare professionals, enabling virtual consultations and data sharing directly through the mirror.

Why This Matters

Health monitoring is often reactive. We go to the doctor only when something feels wrong. OMNIA flips this narrative. It turns daily habits into opportunities for proactive care, catching potential issues before they escalate.

Think about chronic conditions like heart disease or diabetes. Early detection and consistent monitoring are key to better outcomes. OMNIA’s vision makes these steps easy, integrating health insights into your routine without the hassle of appointments.

The Bigger Picture

OMNIA could empower more people to take charge of their health, but two key factors will determine its success:

• Accesibility

While the technology is impressive, cutting-edge technology often comes at a high cost. Its impact depends on affordability and widespread adoption.

• Privacy

A mirror that collects personal health data must ensure that this information remains secure and confidential. Without strong data protection, gaining user trust will be difficult.

A Glimpse into The Future

Still in its concept phase, OMNIA represents a shift toward interconnected health ecosystems, where technology doesn’t just track your health but actively helps you improve it. This is a vision where health becomes a seamless part of daily life, something you live with, learn from, and continuously enhance.

On a Larger Scale…

OMNIA hints at how anonymized data could transform public health. By identifying trends and predicting outbreaks, it has the potential to optimize healthcare systems and benefit entire communities.

Living with Health

OMNIA highlights how health technology can blend effortlessly into our daily routines, turning simple habits into opportunities for better well-being. It’s about more than gadgets; it’s about empowering people to understand themselves and live healthier, every single day.

Loyal, is a biotech company founded by Celine Halioua, on a mission to help our furry friends live longer, healthier lives. They are researching the aging process in dogs and developing innovative treatments to extend their lifespan.

According to scientific research, the traditional "dog years" formula is a myth - dogs actually age faster when young and slower when old.

Loyal has developed an "aging clock" that can accurately measure and compare the aging rates of different dog breeds. Interestingly, larger dog breeds generally have shorter lifespans than smaller breeds. This is because selective breeding has accidentally caused growth issues that lead to faster aging in bigger dogs. Loyal is working to "make the metabolism of a big dog look more like that of a small dog," aiming to slow down the aging process.

Recently, Loyal secured $45 million in funding to accelerate the development of their dog life-extension drugs. This new capital was the last puzzle piece to ensure they could bring LOY-001, the first FDA-approved lifespan extension drug to market in 2025. By studying the mechanisms of aging in our furry friends, Loyal hopes to gain insights that can be translated into human longevity research as well.

Isn't it exciting that their research holds promise for improving and extending the lives of both dogs and humans in the future?

Watch: How to Make Your Dog Live Longer (with science)

Read:

• $125M to extend dog lifespan

• Loyal lands $45m to advance development of dog life extension drugs

In this note, we explore:

• Prevention Matters: Health tests that could potentially save your life.

• Sequel App: Can't wait to give it a try! It's designed to integrate all your health data and offer personalized insights. How cool is that?

• Recommendation: A tool I've been loving lately.

Assess your biomarkers to extend your healthspan

I recommend focusing on prevention for anyone aiming to live longer and healthier lives. As we age, we face risks from four main common aging-related diseases: heart disease, cancer, diabetes, and Alzheimer's. Luckily, there are health tests that can potentially save our lives. Checking these regularly can help detect health risks early and allow us to make lifestyle choices to boost our healthspan and prevent diseases.

These are the tests that might save your life:

1. DNA Sequencing

2. Regular Blood Tests

• ApoB Cholesterol Test

• HbA1c

3. Coronary calcium scan

4. Cancer screening

5. Colonoscopy

6. DEXA scan

7. Brain imaging

1. DNA sequencing

Understand your genetic and biological risk factors through DNA sequencing. 

💡 Your DNA can reveal risks for conditions such as diabetes, heart disease, and hereditary diseases.

🗞️ Whole-genome sequencing is emerging, offering precision scores.

However, with the rise of DNA test companies, it's essential to evaluate their regulations compliance.

DNA Tests that seem compliant: Nebula and Nucleus

2. Regular blood tests

Regular blood tests can help prevent diseases and catch unhealthy trends early, track treatment progress, and assess overall health, providing valuable information for informed healthcare decisions

Regular blood tests - Fitness Insight Blood Test and Basic Metabolic Panel (BMP)

Help monitor biomarkers that affect cardio fitness, metabolism, and overall health

Specific tests - ApoB Cholesterol and the HbA1c

Crucial to detect unhealthy trends early, like assessing heart disease and diabetes risk.

ApoB Cholesterol Test

This LDL cholesterol blood test measures the amount of a certain type of protein of cholesterol called apolipoprotein B-100 (ApoB) in your blood. ApoB protein helps fat get through the walls of arteries forming plaque, which can increase the risk of heart disease & stroke.

HbA1c blood test

It measures average blood sugar levels over the past 3 months. High levels indicate a risk for diabetes. 

Specific tests - Proteomics

Advanced blood analysis techniques, such as proteomics, offer comprehensive insights into a patient's health by measuring numerous proteins simultaneously, aiding in early disease detection and treatment monitoring

3. Coronary calcium scan

This ultrasound of the carotid arteries helps assess the risk of coronary artery disease (CAD) and future cardiovascular events by checking for plaque buildup in neck arteries, which increases stroke and heart attack risk.

4. Cancer screening

Regular screenings can help identify cancer before symptoms appear, increasing the chances of successful treatment and potentially saving lives.

💡 Cancer results in 1 in 6 deaths globally & one of the largest health problems in the world.

Promising advancements include:

- The latest TruDiagnostic partnership with Precision Epigenomics introducing EPISEEK™ a multi-screening cancer liquid biopsy that by looking at trends in molecular patterns that form on our DNA (epigenetic markers) can screen for Prostate, Rectal, Bladder, Breast, Colon, Esophageal, Head & Neck, Pancreas, Lung Squamous Cell Carcinoma, and Lung Adenocarcinoma cancers-

- The Galleri blood test. Using advanced sequencing technology, it detects cancer-related DNA changes early on, enabling early detection of various types of cancer.

However, it's currently available only in the US and undergoing clinical trials in the UK. Let's hope it becomes available in Europe soon!

📢 If you know of any other alternatives in the EU, please share.

5. Colonoscopy

Recommended every 5-10 years starting at age 35-50. Colonoscopies detect and remove colon polyps before they become cancerous, reducing the risk of colorectal cancer.

💡 Colon cancer is the second leading cause of cancer-related deaths worldwide.

• A colonoscopy can detect colorectal cancer early when treatment is most effective.

• It can also diagnose gastrointestinal conditions like IBS & gastrointestinal bleeding.

🥦 Adopting a diet low in sugar and processed meat while high in fiber can further reduce risks. 

6. DEXA Scan

This test does several things:

💡 It's the most accurate way to test your body fat levels.

• It measures visceral fat, the fat around your organs.

• It measures how strong your bones are.

• It assesses your risk of metabolic disease & osteoporosis.

7. Brain imaging

This test uses an MRI to help detect structural abnormalities & can help diagnose the potential for neurological conditions like Alzheimer's, dementia, tumors & strokes.

Resources:

• Investing in Longevity and Extending Your Lifespan

• 6 tests that might save your life - @FitFounder

Sequel - Your personal AI longevity assistant

I'm excited to try this newly released app called Sequel.

Created by @farbood, a biohacker making waves in the X community. He has been biohacking for 25 years, and recently, became one of the first 200 people in the world to receive Follistatin gene therapy at the Mini Circle clinic in the new Próspera City of Roatan, Honduras

Sequel is a longevity assistant for interacting with your health data (whoop data, supplements, lab reports, scans etc)

• It's open-source: You can customize it, check out the code, and see the prompts used to analyze the data.

• It is locally stored: Your data stays yours; Sequel doesn't access or view it. You can run it locally or with OpenAI.

• You can chat with your complete health picture: from blood tests to Whoop data, DEXA scans, and even the therapies or supplements you're taking.

• It keeps track of the data: no need to re-input everything every time you need to ask something; Sequel keeps track of your data for seamless access.

Although still in its early stages, Sequel looks incredibly promising.

Will you join me in giving it a try?

Download it at: withsequel.com

LAST BUT NOT LEAST...

My latest tool pick

dexa.ai

It is a platform that provides access to the knowledge of experts, shared in podcasts. I use it to answer specific questions about health and longevity. I like that it directly links answers to experts, ensuring transparency and credibility. One of my favorite features is the question suggestion feature, which, much like Perplexity, encourages deeper exploration.

Check it out: dexa.ai, and let me know your thoughts!

Understanding the inner body-mind connection

This week, I listened to "The Inner Game of Tennis," a book that delves into the mental strategies behind top athletes' success.

The lessons from this book and the rising trend of athletes teaming up with health brands such as Taylor Fritz's recent partnership with Eight Sleep, and Maria Sharapova's collaboration with AMAN underscore the evolving landscape of sports science and wellness.

💡It's no longer just about training the body; it’s also about nurturing the mind.

Tennis players must balance their thoughts and feelings to perform at their best. They use advanced techniques, focus on quality sleep, and practice mental resilience to be at the top of their game. There is a shift where the focus has expanded beyond just physical training, focusing on optimizing overall well-being.

Leveraging our inner data game

On the other hand, with all the technology available nowadays, achieving peak performance also translates into understanding and leveraging our inner data game.

💡Integrating data-driven approaches into our inner game can unlock new levels of performance and personalization.

Elite athletes are harnessing the power of cutting-edge technologies and expert guidance to gain profound insights into their physiological and psychological states. For instance, tennis player Sloane Stephens has teamed up with WHOOP. The integration of biometric data has become a "game-changer" for Sloane, empowering her to better understand and optimize her body's responses. Getting real-time data and feedback on her recovery, sleep quality, and training, allows her to develop personalized strategies to improve sleep, manage stress, and enhance mental resilience - all essential for sustaining high levels of performance.

Key Insights

• Ease up: Trying too hard can affect our natural learning and performance. Letting things flow naturally is key.

• Trust your instincts, quiet your mind: Instead of micromanaging our bodies with constant instructions, we should learn to trust our subconscious and let our instincts guide us. Trust your body's natural abilities instead of overthinking.

• Observe, don't judge: Observe your thoughts and actions without self-criticism. It helps us learn and improve without all the negative self-talk.

• Focus on feeling: Notice how you feel when performing at your best and use that to replicate success.

• Master your mind, embrace the inner game: The mental battle we play against ourselves is just as important as the physical game. Mastering this inner realm is key to achieving excellence.

Book: The Inner Game of Tennis by. W Timothy Gallwey

Rating: ★★★★★

Partnerships Between Elite Tennis Players and Health/Wellness Brands

• Sloane Stephens: WHOOP

• Taylor Fritz: Eight Sleep

• Maria Sharapova: AMAN, Therabody

• Women's Tennis Association (WTA): WHOOP, Hologic, Modern Health

• Victoria Azarenka: Technogym

• Naomi Osaka: Modern Health

• Jannik Sinner: La Roche-Posay

• Roger Federer: La Roche-Posay

• Chris Evert: Osteo Bi-Flex

Thank you for joining us on this journey towards healthier, longer lives. Our goal is to inspire you and bring you closer to the world of longevity.

Are you ready for this mission?

In this note, we explore:

• My grandma is turning 101

• The AI Drug Discovery Revolution

• Meet the World’s Most Genetically Modified Woman

• Athena DAO's new reproductive health report

• Spotify Founders Invest in A New Longevity Clinic

🗓️ Events Happening Now

• Milan Longevity Summit: March 14-27 | Milan

• Abundance 360 Summit: March 17-21 | Los Angeles

💡 Story

My Grandma is Turning 101

As my grandmother approaches her 101st birthday next week, I couldn't help but imagine reaching that milestone myself one day. This got me thinking a lot about how much our genes influence living long, healthy lives. I have always assumed that if my grandparents lived to be 100, I must have inherited good longevity genes too but it turns out that we have more control over our lifespan than we might realize.

Read the full story: Beyond Inheriting Good Longevity Genes: Celebrating my Grandma's 101st Birthday

🗞️ News

The AI Drug Discovery Revolution: Insilico Medicine Leads with First AI-Designed Drug and Ranks #1 Biotech Company in Fast Company's 2024 World's Most Innovative Companies list

The integration of generative AI in drug discovery is revolutionizing the industry by enhancing precision, speed, and cost-effectiveness.

Insilico Medicine, not only has pioneered the first fully discovered and developed AI drug, but has just been named The #1 Biotech Company in Fast Company's 2024 World's Most Innovative Companies list. This recognition comes amidst a year of groundbreaking achievements, including the publication of their lead drug's story in Nature Biotechnology.

🚀 Why is this a big deal?

AI's integration into drug discovery and development is not only enhancing precision, speed, and cost-effectiveness but also paving the way for innovative therapeutic solutions tailored to individual patient needs.

Read the full story: The AI Drug Discovery Revolution: Insilico Medicine Leads with First AI-Designed Drug and Ranks #1 Biotech Company in Fast Company's 2024 World's Most Innovative Companies list

Chat with the paper: ChatPaperGPT

Watch this video: From Generative AI to Human Clinical Trials: A story of Insilico Medicine's TNIK Program

🗞️ News

Are We Approaching a Gene Therapy Era? Meet the World's Most Genetically Modified Woman

Liz Parrish is the founder and CEO of BioViva Science, a company developing experimental gene therapies aimed at treating biological aging.

She became the first person to try some of these new gene therapies on herself. To demonstrate their safety and efficacy, and help streamline regulatory approval to help more patients access promising treatments earlier.

She has received gene therapies targeting important processes like muscle mass, telomeres, and mitochondria.

⚡Exciting news:

• No adverse side effects were observed from any of the therapies

• By addressing aging at the genetic level, these therapies could help treat multiple age-related diseases and conditions.
  

Read the full story: Are We Approaching a Gene Therapy Era? Meet the World's Most Genetically Modified Woman

🗞️ News

Athena DAO's new reproductive health report: The Mars of oncology are gynecological cancers.

AthenaDAO has just released a report focusing on the critical yet overlooked issue of gynecological cancers.

This report reveals a profound reality: Despite cancer being the most funded area of biomedical research, gynecological cancers have been left behind. These cancers are often diagnosed at later stages due to the absence of effective screening tests leading to limited survival rates, and removing organs such as the uterus and/or ovaries, impacting women's bodies and reproductive health.

It's time to push for innovative solutions, early detection, funding, research, and increased awareness to bridge this gap.

💡 Read the report – Check out their cheat sheet with actionable advice on detecting and preventing gynecological cancers at the end of the report.

AthenaDAO is building an army for change – If you're curious and want to get involved, you can join their Discord community.

💸 Investments

• Spotify Founders Invest in Sand Clinic: A New Longevity Clinic Opening in Stockholm

• LongeVC Backing Ani Biome, an Agetech Startup Focused on Gut Health

• Zephyr lands $111m to advance AI precision medicine platform

• Relation Therapeutics lands $35m to discover osteoporosis drugs with AI

• X-Therma raises $22.4m to scale cryopreservation devices

• Maximon lowers the bar for European longevity investors

• SENISCA raises £3.7 million for rapid development of senotherapeutic platform

🗓️ Events

• Milan Longevity Summit: March 14-27 | Milan

• Abundance 360 Summit: March 17-21 | Los Angeles

• Global Longevity Federation Accelerate Ideas, Partnerships And Opportunities: March 25-26 | Online

• Healthcare Redefined: March 26 | Online

• Roadmaps: Biomarkers of Aging with Mahdi Moqri & Jesse Poganik: March 26 | Online

The upcoming opening of the Sand Clinic in Stockholm, founded by Anna Levander and Jennie Sandqvist, is just around the corner. Inspired and backed by a joint €4m investment from Spotify founders Daniel Ek and Martin Lorentzon, this clinic promises a new era of science-backed treatments and innovations in the heart of the Forskaren Science Center.

Key Innovations

• Personalized Plans: Members of the Sand Clinic can expect comprehensive health services customized to their unique individual needs.

• Data-Driven Platform: Seamlessly integrating cutting-edge technology to enable precise diagnostics and continuous monitoring, facilitating a comprehensive approach to healthcare. Connecting the dots for a more informed and personalized patient experience.

• Advanced Diagnostics and Treatments: Sand Clinic will offer a range of services to assess health risks, prevent diseases, and promote overall well-being. Providing cutting-edge treatments like vascular ultrasound, blood samples, heart and muscle performance checks, vacuum therapy, and red light therapy.

• Evidence-Based Care: By prioritizing science-backed treatments over unproven remedies commonly found in the wellness industry, Sand Clinic upholds a commitment to providing safe, effective, and evidence-based healthcare solutions.

• State-of-the-art facilities located at the Forskaren Science Center: Sand Clinic will be located within the Forskaren Science Center, a hub for life science innovation in the heart of Stockholm. This center is designed to foster collaboration and growth among businesses and researchers in the life sciences sector.

Tesla's Business Model Influence

Drawing inspiration from Tesla's business model, Anna Levander and Jennie Sandqvist are committed to enhancing accessibility to their services. Despite initial monthly fees ranging from €1K to €10K, the duo aims to broaden access by implementing a strategy akin to Tesla's approach:

“Our ambition is, over time, to open up smaller and less costly clinics with the most impactful treatments that we find from our collected data and the procedures we do here.”

Sifted Reports

Longevity on the Rise

The investment from high-profile entrepreneurs highlights the growth potential of the health and biotech sector. With the longevity market expanding into a billion-dollar industry, we witness increasing investor interest in supporting clinics. Daniel Ek's involvement in healthcare is not new; he also co-founded Neko Health, a diagnostics startup specializing in full-body scanning services, securing €60 million in Series A funding through a round led by Lakestar, with participation from Atomico and General Catalyst.

Resources

• Inspired by the insights featured in Sifted’s edition: Exclusive: Daniel Ek's new bet on longevity

• Spotify founders back new Swedish longevity clinic by. Longevity Technology

Insilico Medicine, not only has pioneered the first fully discovered and developed AI drug, but has just been named The #1 Biotech Company in Fast Company's 2024 World's Most Innovative Companies list. This recognition comes amidst a year of groundbreaking achievements, including the publication of their lead drug's story in Nature Biotechnology.

One of the most significant accomplishments is the development of the first drug entirely discovered and designed by artificial intelligence, currently in phase 2 human clinical trials as part of Insilico Medicine's groundbreaking TNIK program. This achievement represents a significant milestone in drug discovery, showcasing the power of AI in accelerating the development of novel therapeutics.

Insilico Medicine's TNIK program has successfully identified and designed a novel molecule for treating fibrotic diseases within an impressive timeframe of just 18 months, from target discovery to preclinical candidate nomination, significantly reducing both time and costs compared to traditional pharma.

Here's why this achievement is a big deal:

• Precision, Speed, and Cost-Effectiveness: The integration of generative AI in drug discovery enhances precision, accelerates development timelines, and reduces costs significantly.

• Tailored Therapeutic Solutions: AI enables the creation of personalized treatment options tailored to individual patient needs through data-driven insights.

• End-to-End AI-Driven Drug Discovery Platform: Insilico Medicine's TNIK program demonstrates the power of a complete AI-driven system for discovering and developing drugs. This approach utilizes Insilico Medicine's advanced end-to-end pipeline, incorporating platforms like PandaOmics for target discovery and Chemistry42 for drug design.

The integration of advanced AI technologies in drug discovery signifies a future where transformative therapies can be developed rapidly and with exceptional accuracy. Insilico Medicine's AI-driven platforms mark a significant shift in how we discover and develop new drugs, offering potential benefits across diverse therapeutic areas.

As we move towards a new era of precision medicine and healthcare innovation, Insilico Medicine's achievements signal a future filled with groundbreaking solutions for global challenges. Alex Zhavoronkov, the founder and CEO of Insilico Medicine, anticipates that “these breakthroughs will go way beyond biotech”.

You can find the paper published in Nature Biotechnology and interact with the paper through their ChatPaperGPT

Resources

Read

• Generative Artificial Intelligence for Drug Discovery: How the First AI-Discovered and AI-designed Drug Progressed to Phase 2 Clinical Testing

• Data Repository for TNIK anti-fibrotic program

• The most innovative companies in biotech in 2024

Meet Liz Parrish, the founder and CEO of BioViva Science, a company at the forefront of developing cutting-edge gene therapies to combat biological aging.

Driven by a personal mission to revolutionize healthcare, Liz courageously became the first person to undergo experimental gene therapies, to demonstrate their safety and efficacy, and pave the way for quicker regulatory approvals, ensuring more patients can access life-changing treatments sooner.

She has received gene therapies targeting important processes like muscle mass, telomeres, and mitochondria.

- Follistatin Therapy increased her muscle size, uplifting her metabolic health.

- Telomerase Therapy lengthened her telomeres to those of a healthy 25-year-old.

- Klotho improved her inflammation and blood sugar markers.

- PGC-1α No individual effects were mentioned, but it aims to reduce oxidative stress and boost mitochondria for increased energy in cells

The good news

• No Adverse Effects: Remarkably, none of the therapies has led to any negative side effects until now.

• Potential Impact: By addressing aging at the genetic level, these therapies hold promise in treating a spectrum of age-related diseases and conditions, offering hope for a healthier and more vibrant future.

While the field of genetic interventions is still evolving, the strides made by pioneers like Liz Parrish pave the way for a new era in personalized genetic interventions.

Resources

• Inspired by the insights featured in: The World’s Most Genetically Modified Person - Authored by Adam Alonzi and Ryan Hall

Disclaimers

• It is essential to consult healthcare professionals before considering any experimental gene therapies.

• The efficacy and safety of gene therapies may vary among individuals, emphasizing the need for thorough research and clinical oversight.

• The information provided is for educational purposes and does not constitute medical advice.

As my grandmother approaches her 101st birthday next week, I couldn't help but imagine reaching that milestone myself one day. This got me thinking about how much our genes influence living long, healthy lives, and I've realized that we have more control over our lifespan than we might realize.

We've all heard that certain traits run in families, right? Things like eye color or height are passed down from parent to child. Many of us also assume the same applies to longevity – if your grandparents lived to be 101, you must have inherited "good longevity genes" too.

This idea isn't entirely off the mark. Dr. Nir Barzilai's groundbreaking research provides insights into how our genes affect aging and overall health. Although his studies reveal that our genetic makeup significantly impacts both how we age and our overall healthspan, he emphasizes that while genetics matter, lifestyle factors are just as important.

A study conducted by Calico Labs challenges our assumptions about genetics and lifespan. Scientists analyzed hundreds of family histories and found evidence that relatives tend to live similar lengths of time. But then they noticed something interesting – husbands and wives also often had very similar lifespans, even though they were not biologically related.

This led researchers to realize an important factor; a phenomenon known as Assortative Mating. Essentially, we tend to choose partners who are similar to us, not just in personality and behavior, but also in physical appearance, education, socioeconomic status, and even some genetic factors. So couples end up sharing not just a life together, but also an entire lifestyle and environment. When researchers accounted for the effect of couples influencing each other, they found that genetics only accounts for 7% of how long we live, which is quite different from the previously estimated value of 20% to 30%.

I found this surprising because I have always assumed that if my grandparents lived to be 100, I must have inherited good longevity genes too. While genetics certainly play a role, it seems that the happy, healthy lifestyle and environment they cultivated for decades were also crucial factors in their long lives. My grandma, for instance, doesn't smoke, eats healthy, and stresses little, which is most probably contributing to her well-being. However, she didn't prioritize regular exercise throughout her life. I can't help but wonder how much more optimized her health could have been if physical activity had been a part of her routine.

So, next time someone celebrates their 101st birthday, remember that it's not just about our genes. Our lifespan is significantly shaped by the environment and lifestyle choices we make. Focusing on things like diet, exercise, sleep, low stress, and strong relationships remains the best way to promote longevity until we have more advanced rejuvenation therapies.

Resources:

• Estimates of the Heritability of Human Longevity Are Substantially Inflated due to Assortative Mating

• A study in human genetics demonstrates limited influence on longevity - Calico

• The Latest Updates in Longevity Research with Dr. Eric Verdin - Longevity by Design. Inside Tracker

• Genetic influence on human lifespan and longevity

We often accept pain and illness as inevitable parts of aging, but I believe we have the power to change that.

Taking control of our health

For me, it all begins with prevention and optimization. Why wait for sickness to happen when we can take proactive steps today to protect our future health? I’ve learned that we have more control over our well-being than we think.

Did you know that genetics only determine about 7% of how long and healthy we live? The remaining 93% is influenced by our daily choices—what we eat, how we move, our environment, and how we manage stress. These factors can help us stay active and vibrant, regardless of what our genes say.

The science of longevity is here

But lifestyle alone isn’t enough. There’s an exciting world of longevity science unfolding right now. Advances in CRISPR technology, genomics, AI, and other innovations are pushing the boundaries of what’s possible. We’re on the brink of transforming how we age, and I truly believe, this is only the beginning.

The first step: How I’m bringing my longevity passion to life

Five years ago, my curiosity about longevity turned into a personal mission. I wanted to understand how we could live healthier, longer lives. That’s how biocompass was born. It’s my way of bringing together everything I’ve learned about longevity science, health solutions, and the best ways to stay at our peak—so that you can take control of your own journey.

biocompass is a curated collection of the latest breakthroughs in health-tech and longevity. Bringing together products, experts, and leading wellness centers to help you navigate the overwhelming world of consumer health. The mission is simple: to empower you to take control of your health and longevity without feeling lost in the noise.

Join the movement

I believe the future of aging will look entirely different—where growing older isn’t about decline but about living vibrantly at every stage of life. And you can be a part of that transformation.

Subscribe to the newsletter to stay ahead of the curve. Every week, we’ll dive into the latest breakthroughs in longevity, wellness, and optimization—giving you the tools to live your best life for years to come. Let's navigate the future of health together!

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Welcome to biocompass, your compass for a healthier, longer life. Our mission is to empower you with the latest updates and advancements in aging and longevity. From cutting-edge insights to innovative products, top-tier centers, and experts, we provide you with everything you need to make informed decisions about your health and wellness.

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